Unravelling the genetic landscape of cervical insufficiency: Insights into connective tissue dysfunction and hormonal pathways
Cervical insufficiency in non-syndromic patients is not attributed to a single connective tissue gene variant in a Mendelian fashion but rather to the cumulative effect of multiple inherited gene variants highlighting the significance of the connective tissue pathway in the multifactorial nature of CI. PGR or NR3C1 variants may contribute to the pathophysiology of CI and/or preterm birth through the impaired progesterone action pathways, opening new perspectives for targeted interventions and enhanced clinical management strategies of this condition.
Authors
- Anna Kornete (ORCID: https://orcid.org/0000-0002-5363-8134)
- Anna Miskova (ORCID: https://orcid.org/0000-0002-1592-1852)
- Dmitrijs Rots (ORCID: https://orcid.org/0000-0002-4890-9147)
- Meilė Minkauskienė (ORCID: https://orcid.org/0000-0003-1056-0522)
- Alessia Rota (ORCID: https://orcid.org/0000-0001-6602-3852)
- Zita Strelcoviene (ORCID: https://orcid.org/0000-0001-9773-311X)
- Linda Gailīte (ORCID: https://orcid.org/0000-0002-7219-1294)
- Zita Krūmiņa
- Ludmila Voložonoka (ORCID: https://orcid.org/0000-0003-0413-1481)
- Inga Kempa (ORCID: https://orcid.org/0000-0003-4456-5778)
- Dace Rezeberga
- Baiba Vilne (ORCID: https://orcid.org/0000-0002-1084-7067)
- Līvija Bārdiņa (ORCID: https://orcid.org/0000-0002-8211-9798)
Institutions
- Lithuanian University of Health Sciences (LT)
- Riga East University Hospital (LV)
- Children's Clinical University Hospital (LV)
- Riga Stradiņš University (LV)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1371/journal.pone.0310718
- Citations
- 1
- Primary Topic
- Preterm Birth and Chorioamnionitis
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Latvijas Zinātnes Padome