Berberine potentiates liver inflammation and fibrosis in the PI*Z hAAT transgenic murine model
BBR exacerbated liver inflammation and fibrosis specifically in Pi*Z mice. This adverse effect may be associated with the activation of unfolded protein response and mTOR. This study implicates that BBR should be avoided by AATD patients.
Authors
- Alek M. Aranyos (ORCID: https://orcid.org/0000-0002-3130-1573)
- Mark Brantly (ORCID: https://orcid.org/0000-0003-0189-1565)
- Karina A. Serban (ORCID: https://orcid.org/0000-0002-9372-3034)
- Jungnam Lee (ORCID: https://orcid.org/0000-0002-3877-6600)
- Yuanqing Lu (ORCID: https://orcid.org/0000-0001-8196-8918)
- N. Mohammad
Institutions
- University of Florida (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1371/journal.pone.0310524
- Citations
- 4
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 1.79
Funders
- Alpha-1 Foundation