Distribution of MRI-derived T2 values as a biomarker for in vivo rapid screening of phenotype severity in mdx mice
Use of this rapid, non-invasive, semi-automated MR image segmentation and analysis pipeline has the potential to transform preclinical studies, allowing for pre-screening of dystrophic mice prior to study enrollment to ensure more uniform muscle disease pathology across treatment groups, improving study outcomes.
Authors
- Alexis R. Demonbreun (ORCID: https://orcid.org/0000-0001-6823-125X)
- Lauren A. Vaught (ORCID: https://orcid.org/0000-0001-8634-9139)
- Emily A. Waters (ORCID: https://orcid.org/0000-0003-3479-6054)
- Chad R. Haney (ORCID: https://orcid.org/0000-0001-5981-2925)
- Elizabeth M. McNally (ORCID: https://orcid.org/0000-0002-1221-719X)
Institutions
- Northwestern University (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1371/journal.pone.0310551
- Citations
- 1
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Silicon Valley Community Foundation
- Amgen
- Pfizer
- AstraZeneca
- Northwestern University
- Cytokinetics
- National Institutes of Health
- National Cancer Institute