Repeated intrathecal injections of peripheral nerve-derived stem cell spheroids improve outcomes in a rat model of traumatic brain injury
Our findings suggest that repeated intrathecal injections of PNSC spheroids can significantly enhance neural recovery after TBI. This effect is mediated by the diverse neurotrophic factors secreted by PNSC spheroids. Thus, the strategy of combining therapeutic cell delivery with multiple intrathecal injections holds promise as a novel clinical treatment for TBI recovery.
Authors
- Eun Ji Roh (ORCID: https://orcid.org/0000-0002-6337-9754)
- Inbo Han (ORCID: https://orcid.org/0000-0002-0834-9325)
- Byeong Gwan Song
- Kwangrae Cho
- Young‐Il Yang
- Kwang‐Sook Park (ORCID: https://orcid.org/0000-0002-3309-9751)
- Wonjin Lee (ORCID: https://orcid.org/0000-0002-6240-7370)
- Yerin Yu
- Gyubin Kim
- Hae Eun Shin
- Young-Hu Ha
- Joon-Hyuk Jung
Institutions
- Inje University (KR)
- Dong-Eui University (KR)
- Youngsan University (KR)
- Inje University Busan Paik Hospital (KR)
- CHA University Bundang Medical Center (KR)
- Stem Cell Institute (PA)
- CHA University (KR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1186/s13287-024-03874-2
- Citations
- 6
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 2.21