Acetylsalicylic acid and dihydroartemisinin combined therapy on experimental malaria-associated acute lung injury: analysis of lung function and the inflammatory process
Therapy with ASA maintained lung morpho-functional impairment triggered by PbNK65 infection, leading to a large influx of inflammatory monocytes to the lung tissue. Based on its deleterious effects in experimental MA-ALI, ASA administration or its treatment maintenance might be carefully reconsidered and further investigated in human malaria cases.
Authors
- Flávia Lima Ribeiro-Gomes (ORCID: https://orcid.org/0000-0003-0297-6341)
- Helena Oliveira (ORCID: https://orcid.org/0000-0003-2744-3496)
- Ana Carolina Bastos de Lima (ORCID: https://orcid.org/0000-0001-6705-4415)
- Marcos Vinícius Rangel-Ferreira
- Johnatas D. Silva (ORCID: https://orcid.org/0000-0003-4379-4237)
- Camila Nunes Batista
- Rodrigo J.R.X. Freitas (ORCID: https://orcid.org/0009-0009-6743-6865)
- Patrícia R. M. Rocco (ORCID: https://orcid.org/0000-0003-1412-7136)
- Marcelo Pelajo
- Tatiana Maron-Gutierrez
- Maiara Nascimento Lima
- Hugo Caire de Castro Faria-Neto
- Débora Gonçalves Xisto
- Beatriz A.B.R. Passos
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Malaria Journal
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1186/s12936-024-05017-7
- Citations
- 1
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Fundação Oswaldo Cruz