Association between subcortical nuclei volume changes and cognition in preschool-aged children with tetralogy of Fallot after corrective surgery: a cross-sectional study
Our findings indicate that subcortical nuclei structural injuries possibly potentially stemming from cardiac anatomical abnormalities, are associated with impaired working memory in preschool-aged children with TOF. The LAM in particular may serve as a potential biomarker for neurocognitive deficits in TOF, offering predictive value for future neurodevelopmental outcomes, and shedding light on the neurophysiological mechanisms of these cognitive impairments.
Authors
- Mingcui Fu
- Jia An (ORCID: https://orcid.org/0000-0001-6138-8254)
- Xuming Mo (ORCID: https://orcid.org/0000-0002-2264-6123)
- Ming Yang (ORCID: https://orcid.org/0000-0001-5307-8272)
- Liang Hu (ORCID: https://orcid.org/0000-0002-0013-7440)
- Huijun Li (ORCID: https://orcid.org/0009-0007-8067-4556)
- Yaqi Zhang (ORCID: https://orcid.org/0000-0002-8281-3122)
- Zhen Zhang (ORCID: https://orcid.org/0000-0002-1644-5085)
- Lu Fan (ORCID: https://orcid.org/0009-0002-1365-0996)
- Xinyu Cai (ORCID: https://orcid.org/0009-0002-9611-6237)
- Nishant Patel (ORCID: https://orcid.org/0000-0002-2573-7469)
- Minghui Tang (ORCID: https://orcid.org/0000-0003-2421-8314)
- Kede Wu
- Ye Lin
- Meijiao Zhu
Institutions
- Nanjing Children's Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- The Italian Journal of Pediatrics/Italian journal of pediatrics
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1186/s13052-024-01764-0
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Nanjing Medical University
- Jiangsu Provincial Key Research and Development Program