Propofol binds and inhibits skeletal muscle ryanodine receptor 1
Propofol demonstrated direct binding and inhibition of RyR1 at clinically plausible concentrations, consistent with the hypothesis that propofol partially mitigates malignant hyperthermia by inhibition of induced Ca<sup>2+</sup> flux through RyR1.
Authors
- Roderic G. Eckenhoff (ORCID: https://orcid.org/0000-0002-5581-746X)
- Paul D. Allen (ORCID: https://orcid.org/0000-0001-6915-1390)
- Grace Brannigan (ORCID: https://orcid.org/0000-0001-8949-2694)
- Kellie A. Woll (ORCID: https://orcid.org/0000-0003-4037-1327)
- Yu S. Chen
- Thomas T. Joseph (ORCID: https://orcid.org/0000-0003-1323-3244)
- Omid Haji‐Ghassemi (ORCID: https://orcid.org/0000-0003-0116-005X)
- Filip Van Petegem (ORCID: https://orcid.org/0000-0003-2728-8537)
- Weiming Bu
Institutions
- Rutgers, The State University of New Jersey (US)
- University of British Columbia (CA)
- University of Tennessee at Knoxville (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- British Journal of Anaesthesia
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1016/j.bja.2024.06.048
- Citations
- 3
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Foundation for Anesthesia Education and Research
- University of Wisconsin-Madison
- National Institutes of Health
- National Institute of General Medical Sciences