Interleukin-12p40 deficiency attenuates myocardial ferroptosis in doxorubicin-induced chronic cardiomyopathy by inhibiting Th17 differentiation and interleukin-17A production
Interleukin-12p40 deficiency protects against DICCM by inhibiting Th17 differentiation and the production of IL-17A, which plays critical roles in cardiomyocyte ferroptosis in DICCM via activating TRAF6/MAPK/P53 signalling. Our study may provide novel insights for the identification of therapeutic targets for treating DICCM in the clinic.
Authors
- Mengmeng Zhao
- Menglong Wang (ORCID: https://orcid.org/0000-0002-7760-7156)
- Shanshan Peng (ORCID: https://orcid.org/0000-0001-8630-1725)
- Zihui Zheng (ORCID: https://orcid.org/0000-0002-9679-8373)
- Juan‐Juan Qin (ORCID: https://orcid.org/0000-0002-9823-2373)
- Yao Xu (ORCID: https://orcid.org/0000-0002-8275-4652)
- Wei Cheng (ORCID: https://orcid.org/0000-0002-1475-4079)
- Jishou Zhang (ORCID: https://orcid.org/0000-0001-6878-6263)
- Jun Wan (ORCID: https://orcid.org/0000-0003-4865-783X)
- Wei Pan (ORCID: https://orcid.org/0000-0001-7353-3498)
- Zheng Yin (ORCID: https://orcid.org/0009-0000-9640-5034)
- Wen Ding (ORCID: https://orcid.org/0000-0002-9514-6445)
- Jianfang Liu (ORCID: https://orcid.org/0000-0001-8325-0360)
- Siqi Liu (ORCID: https://orcid.org/0000-0002-4184-175X)
Institutions
- Cardiovascular Institute Hospital (JP)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1093/cvr/cvae208
- Citations
- 14
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 3.37
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Wuhan University
- Zhongnan Hospital of Wuhan University
- Institute of Hydrobiology
- Renmin Hospital of Wuhan University