Post-Coronavirus Disease Autoimmunity-associated Morvan’s Syndrome

A lot of autoimmune conditions have been found to be associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There are multiple cases of autoimmune and autoinflammatory diseases reported after the coronavirus disease 2019 (COVID-19) pandemic. Autoimmune neurological presentations have also been reported but are very rare. Morvan's syndrome is a life-threatening autoimmune disease and is very rare. Morvan's syndrome is classically characterized by neuromyotonia, dysautonomia, insomnia, and neuropsychiatric symptoms. Leucine-rich glioma-inactivated protein 1 (LGI1) and contactin-associated protein 2 (CASPR2) autoimmunity has also been associated with Morvan's syndrome. We hereby report an interesting case of a male patient in his 40s, who had a history of COVID-19 infection, following which he had bilateral lower-limb weakness and pain, with profuse sweating, and was later diagnosed as a case of SARS-CoV-2-associated Morvan's syndrome.

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Journal
Journal of the Association of Physicians of India
Published
2024-09-01
DOI
https://doi.org/10.59556/japi.72.0623
Primary Topic
Autoimmune Neurological Disorders and Treatments
Type
article
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article

Post-Coronavirus Disease Autoimmunity-associated Morvan’s Syndrome

Rishikesh Dessai, Kunal Chawla, Shipra Gulati, Laxmikant Ramkumarsingh Tomar et al.
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Journal of the Association of Physicians of India
Autoimmune Neurological Disorders and Treatments
article

Post-Coronavirus Disease Autoimmunity-associated Morvan’s Syndrome

Rishikesh Dessai, Kunal Chawla, Shipra Gulati, Laxmikant Ramkumarsingh Tomar, Kamal Jain, Sruthi Sl Yalamanchili
article en

Abstract

A lot of autoimmune conditions have been found to be associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There are multiple cases of autoimmune and autoinflammatory diseases reported after the coronavirus disease 2019 (COVID-19) pandemic. Autoimmune neurological presentations have also been reported but are very rare. Morvan's syndrome is a life-threatening autoimmune disease and is very rare. Morvan's syndrome is classically characterized by neuromyotonia, dysautonomia, insomnia, and neuropsychiatric symptoms. Leucine-rich glioma-inactivated protein 1 (LGI1) and contactin-associated protein 2 (CASPR2) autoimmunity has also been associated with Morvan's syndrome. We hereby report an interesting case of a male patient in his 40s, who had a history of COVID-19 infection, following which he had bilateral lower-limb weakness and pain, with profuse sweating, and was later diagnosed as a case of SARS-CoV-2-associated Morvan's syndrome.

Journal of the Association of Physicians of IndiaVol. 72(9)
Sir Ganga Ram Hospital (IN)
Good health and well-being
Openalex Percentile: Top 75%
Autoimmune Neurological Disorders and Treatments
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Post-Coronavirus Disease Autoimmunity-associated Morvan’s Syndrome — Rishikesh Dessai, Kunal Chawla, et al. · Journal of the Association of Physicians of India (2024) | TGRS Research Map | TGRS