Slow depolarizing electrical stimuli reveal differential time courses of nociceptor recovery after prolonged topical capsaicin in human skin
Sinusoidal electrical stimulation can still activate small diameter axons desensitized to heat after 4 consecutive days of topical 8% capsaicin application and reveals differential temporal functional regeneration of C-nociceptor sub-types. Electrical sinusoidal stimulation may detect such axons that no longer respond to heat stimuli in neuropathic skin.
Authors
- Richard W. Carr (ORCID: https://orcid.org/0000-0001-8617-9133)
- Roman Rukwied (ORCID: https://orcid.org/0000-0003-4118-497X)
- Martin Schmelz (ORCID: https://orcid.org/0000-0002-3536-8177)
- Divya Tumbala Gutti
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
Publication Details
- Journal
- European Journal of Pain
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1002/ejp.4726
- Citations
- 4
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- Deutsche Forschungsgemeinschaft