<scp>miR</scp>‐133b as a potential regulator of a synaptic <scp>NPTX2</scp> protein in Alzheimer's disease
A synaptic protein, Neuronal Pentraxin 2 (NPTX2), has emerged as a pivotal biomarker for Alzheimer's dementia (AD). We identified candidate miRNAs targeting NPTX2 and performed association and mediation analyses using multi-omics data (N = 702). Among 44 candidate miRNAs, miR-133b was significantly associated with AD and Braak positivity. Higher miR-133b expression was also associated with higher NPTX2 gene expression and better cognition. Mediation analysis showed that miR-133b partially influences AD and cognition through the NPTX2 protein. Our integrated approach suggests a potential role of miR-133b in synaptic integrity and offers new insights into AD pathogenesis.
Authors
- SangYun Kim (ORCID: https://orcid.org/0000-0002-9101-5704)
- Sang‐Won Han (ORCID: https://orcid.org/0000-0002-8299-9481)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Paula J. Bice (ORCID: https://orcid.org/0000-0001-5357-9966)
- Kwangsik Nho (ORCID: https://orcid.org/0000-0002-7624-3872)
- Young Ho Park (ORCID: https://orcid.org/0000-0002-2756-1786)
- David A. Bennett
Institutions
- Rush University Medical Center (US)
- Hallym University (KR)
- Seoul National University Bundang Hospital (KR)
- Hallym University Chuncheon Sacred Heart Hospital (KR)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1002/acn3.52175
- Citations
- 9
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- National Research Foundation
- Hallym University
- National Research Foundation of Korea
- Hallym University Medical Center
- Ministry of Science and ICT, South Korea
- National Institute on Aging