Immunosuppressive effects of triptolide via interleukin-2/receptor signaling
These findings collectively emphasized that TP interfered IL-2/IL-2Rα interactions, down-regulated IL-2Rα expression, and inhibited IL-2R signaling pathways activation, thereby leading to the immune cells being desensitized to rhIL-2 and exhibiting immunosuppressive properties.
Authors
- Ying Xiong (ORCID: https://orcid.org/0000-0002-4255-4728)
- Nandani Darshika Kodithuwakku (ORCID: https://orcid.org/0000-0003-4402-0751)
- Jiao Chen (ORCID: https://orcid.org/0000-0003-1952-7868)
- Yanxia Ding
- Yi Yin
- Jiagang Lv
- Juan Wang (ORCID: https://orcid.org/0000-0002-2531-2188)
Institutions
- Wannan Medical College (CN)
- Nanjing University of Chinese Medicine (CN)
- Ministry of Health, Nutrition and Indigenous Medicine (LK)
- University of Colombo (LK)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1080/08923973.2024.2373219
- Citations
- 3
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- National Natural Science Foundation of China