Remote electrical neuromodulation to treat children and adolescents with migraine in the emergency department: A randomized double‐dummy pilot trial
We demonstrated the feasibility and acceptability of our trial protocol and of using REN to treat youth presenting to the ED with migraine. The parallel-group design generated a higher recruitment rate than the crossover design. Our preliminary efficacy and safety data suggest that REN could be non-inferior to typical care, but we were not powered for these outcomes. Further research on REN's use in the ED setting is warranted.
Authors
- Jonathan Kuziek (ORCID: https://orcid.org/0000-0003-1368-9102)
- Kathryn A. Birnie (ORCID: https://orcid.org/0000-0002-8223-8834)
- Samina Ali (ORCID: https://orcid.org/0000-0002-0595-364X)
- Prachi Khanna (ORCID: https://orcid.org/0000-0003-0196-0508)
- Serena L. Orr (ORCID: https://orcid.org/0000-0002-2879-811X)
- Andrew D. Hershey (ORCID: https://orcid.org/0000-0002-1598-7536)
- Adam Kirton (ORCID: https://orcid.org/0000-0001-5209-3374)
- Stephen B. Freedman (ORCID: https://orcid.org/0000-0003-2319-6192)
- Tolulope T. Sajobi (ORCID: https://orcid.org/0000-0002-5696-5552)
- Eva Anderson
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University of Alberta (CA)
- University of Calgary (CA)
- Alberta Children's Hospital (CA)
- London School of Hygiene & Tropical Medicine (GB)
- Women and Children’s Health Research Institute (CA)
- Ontario Brain Institute (CA)
- Alberta Children's Hospital Research Institute
- Hotchkiss Brain Institute (CA)
- Carleton University (CA)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Headache The Journal of Head and Face Pain
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1111/head.14838
- Citations
- 3
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Amgen
- Eli Lilly and Company
- Pfizer
- Teva Pharmaceutical Industries
- Children's Hospital Foundation
- American Headache Society
- Upsher-Smith
- University of Cambridge
- Alberta Children's Hospital Foundation
- H. Lundbeck A/S
- National Institutes of Health
- Alberta Children's Hospital Research Institute
- Cumming School of Medicine, University of Calgary
- Canadian Institutes of Health Research