O69 THE REGULATORY ROLE OF CIRCULAR RNAS IN RESPONSE TO RAAS INHIBITORS

Circular RNAs (circRNAs) are a class of non-coding RNA that may play an important role in disease progression and diagnosis. This study aimed to investigate the role of renal circRNAs in hypertension and to identify circRNAs pathways explaining chronic reset in blood pressure. Two groups of young spontaneously hypertensive rats (SHR) were used: rats treated with or without losartan (RAAS inhibitor, n = 18 in each group). Through established circRNA identification and quantification tools, we identified five significant circular RNA candidates (P < 0.05), each aligning with differentially expressed and biologically significant miRNA. Furthermore, these candidate circRNAs aligned with expression pathways found in both treatment and control groups. In conclusion, this study identified several circRNAs which may play an important role in blood pressure regulation. It may advance our understanding of circRNAs in mediating losartan-induced blood pressure reduction. Future studies on validation, expression networking and methylome analysis may shed light on these circRNAs’ significance and identify potential therapeutic biomarkers.