IMPACT OF THE BOTULINUM NEUROTOXIN INJECTIONS ON PATIENTS WITH DEPRESSION: THERAPEUTIC MECHANISMS AND POSSIBLE FUTURE PERSPECTIVE

Background: Despite the fact that today's medicine is constantly developing in all directions, there are still some diseases that burden humanity and interfere with daily life, like Depression. Existing treatment tactics are often ineffective, and Botox injections in such cases are an experimental method. Objectives: Our goal is to review previous researches and make this information available on a larger scale so that clinicians can access similar therapies for use in unconventional cases. The purpose of the study was not to directly cure depression, but to evaluate the positive impact that manipulations carried out for aesthetic purposes would have on their general mood and condition. Our attention was especially drawn to the fact that research on this topic has not been conducted in our country yet. Methods: The study involved 15 participants and it lasted on average two months. The Beck Depression Inventory (BDI) Questionnaire, in total 21 question, was used for assessment, just like our predecessors. Results: The results, to our delight, gave us very interesting feedback, based on which we can assume the positive contribution of Botox in the management of patients with depression. BoNT/A injections led to significant improvement of self-rated depression score by using Beck Depression Inventory (BDI). The response rates of BoNT/A were 34%. From the literature, we know that positive results in previous studies ranged from 13% to 52%. Conclusion: Botulinum Neurotoxin therapy shows promise as a novel approach to treating depression. While further research is needed to establish its effectiveness, Botox may offer a unique and potentially valuable option for individuals struggling with depression.