Mechanism of norcantharidin intervention in gastric cancer: analysis based on antitumor proprietary Chinese medicine database, network pharmacology, and transcriptomics
Norcantharidin, as an effective component of anti-tumor pCm, exerts its therapeutic effects on GC by influencing biological processes such as cell adhesion, migration, and inflammation. This study provides a foundation and research strategy for the post-marketing re-evaluation of antitumor pCms.
Authors
- Chao Wu (ORCID: https://orcid.org/0000-0002-2219-5203)
- Xinkui Liu (ORCID: https://orcid.org/0000-0002-0609-6651)
- Yiyan Zhai (ORCID: https://orcid.org/0000-0003-0134-2734)
- Fanqin Zhang
- Tieshan Wang (ORCID: https://orcid.org/0000-0001-9745-2027)
- Jiarui Wu (ORCID: https://orcid.org/0000-0002-1617-6110)
- Siyu Guo (ORCID: https://orcid.org/0000-0001-6995-0352)
- Haojia Wang (ORCID: https://orcid.org/0000-0002-1457-8458)
- Xiaomeng Zhang (ORCID: https://orcid.org/0000-0002-4190-2751)
- Jingyuan Zhang (ORCID: https://orcid.org/0000-0001-7161-194X)
- Rui Shi (ORCID: https://orcid.org/0000-0002-9374-0897)
- Xiaoguang Sheng
- Jiaqi Huang (ORCID: https://orcid.org/0000-0002-3778-2398)
- Jiying Zhou (ORCID: https://orcid.org/0000-0003-1063-4181)
- Yifei Gao (ORCID: https://orcid.org/0009-0007-8770-7162)
- Chuanqi Qiao
- Zhengsen Jin
- Keyan Chai
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1186/s13020-024-01000-1
- Citations
- 6
- Primary Topic
- Beetle Biology and Toxicology Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China
- Ministry of Education of the People's Republic of China
- State Administration of Traditional Chinese Medicine of the People's Republic of China
- National Ethnic Affairs Commission of the People's Republic of China