Identifying immune checkpoints on dysregulated T-cells as prognostic biomarkers for multiple myeloma patients with COVID-19
The prolonged T cell dysregulation after severe SARS-CoV-2 infection highlights the close surveillance from reinfection in MM patients even during convalescence. PD-1 and TIGIT on CD8+ T cells could be important prognostic factors to stratify prognosis in MM patients with COVID-19. Moreover, immunotherapy may downregulate the expression of exhausted checkpoints PD-1 and TIGIT, leading to T cell overactivation and severe COVID-19.
Authors
- Fujing Zhang (ORCID: https://orcid.org/0000-0002-7427-7905)
- Xuan Wang (ORCID: https://orcid.org/0000-0002-1542-3642)
- Xianghong Jin (ORCID: https://orcid.org/0000-0003-3140-5521)
- Huiwen He (ORCID: https://orcid.org/0000-0001-5781-4505)
- Junling Zhuang (ORCID: https://orcid.org/0000-0002-1228-0551)
- Shuangjiao Liu
- Haolong Li (ORCID: https://orcid.org/0000-0002-7865-3306)
- Ziping Li (ORCID: https://orcid.org/0000-0003-0341-6098)
- Yuhang Song
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-17
- DOI
- https://doi.org/10.3389/fimmu.2024.1448653
- Citations
- 2
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.78