Managing the largest school-based COVID-19 outbreak: insights and mitigation strategies

The COVID-19 pandemic, caused by SARS-CoV-2, has significantly impacted educational environments due to their role in community transmission. Early reports indicated low transmission rates in schools, but subsequent studies showed variability, including significant outbreaks like the one in Israel. This study investigates a large COVID-19 outbreak in a boarding school in Brazil, analyzing transmission dynamics and the effectiveness of control measures such as mass testing and isolation. A total of 291 individuals from the school community were tested, revealing an overall infection rate of 64.6%. Initial cases were identified through antigen testing, followed by extensive RT-qPCR testing. Mass testing and timely isolation of infected individuals significantly reduced transmission rates. Whole-genome sequencing was performed on seven positive samples, and environmental contamination was confirmed, with 11 of 35 surface samples testing positive for SARS-CoV-2. The outbreak was controlled within 30 days through rigorous testing, isolation, and environmental disinfection. The study emphasizes the importance of mass testing, including asymptomatic individuals, and highlights the role of environmental contamination in transmission. The findings contribute to understanding COVID-19 outbreaks in educational settings and provide practical insights into managing future outbreaks through comprehensive testing and control strategies. These results may guide policymakers and public health officials in improving pandemic response measures in similar environments.