Sensing data and methodology from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson’s Disease (ADAPT-PD) clinical trial
Adaptive deep brain stimulation (aDBS) is an emerging advancement in DBS technology; however, local field potential (LFP) signal rate detection sufficient for aDBS algorithms and the methods to set-up aDBS have yet to be defined. Here we summarize sensing data and aDBS programming steps associated with the ongoing Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) pivotal trial (NCT04547712). Sixty-eight patients were enrolled with either subthalamic nucleus or globus pallidus internus DBS leads connected to a Medtronic Percept<sup>TM</sup> PC neurostimulator. During the enrollment and screening procedures, a LFP (8-30 Hz, ≥1.2 µVp) control signal was identified by clinicians in 84.8% of patients on medication (65% bilateral signal), and in 92% of patients off medication (78% bilateral signal). The ADAPT-PD trial sensing data indicate a high LFP signal presence in both on and off medication states of these patients, with bilateral signal in the majority, regardless of PD phenotype.
Authors
- Kyle T. Mitchell (ORCID: https://orcid.org/0000-0003-4788-1581)
- Michelle Case
- Martijn Beudel (ORCID: https://orcid.org/0000-0002-2488-7051)
- Jill L. Ostrem (ORCID: https://orcid.org/0000-0001-7018-9521)
- Nagaraja Sarangmat
- Adolfo Ramirez–Zamora (ORCID: https://orcid.org/0000-0001-9253-3899)
- Robert S. Raike
- Todd M. Herrington (ORCID: https://orcid.org/0000-0001-9489-7418)
- Scott R. Stanslaski (ORCID: https://orcid.org/0000-0002-3513-2391)
- Elena Moro (ORCID: https://orcid.org/0000-0002-7968-5908)
- Alfonso A. Fasano (ORCID: https://orcid.org/0000-0001-5346-0180)
- Rebekah L. S. Summers (ORCID: https://orcid.org/0000-0002-1783-3362)
- Leonardo Almeida (ORCID: https://orcid.org/0000-0002-0921-887X)
- Simon J Little (ORCID: https://orcid.org/0000-0001-6249-6230)
- Michal Gostkowski
- Travis Hassell
- Lisa Tonder
- Helen M Bronte-Stewart (ORCID: https://orcid.org/0000-0002-1839-4541)
- Ye Tan
- Nathan Morelli
Institutions
- University of Minnesota (US)
- Cleveland Clinic (US)
- UF Health Shands Hospital (US)
- Harvard University (US)
- Duke University (US)
- University of California, San Francisco (US)
- Toronto Western Hospital (CA)
- Centre Hospitalier Universitaire de Grenoble (FR)
- University of Florida Health (US)
- Massachusetts General Hospital (US)
- Medtronic (United States) (US)
- Oxford University Hospitals NHS Trust (GB)
- Grenoble Institute of Neurosciences (FR)
- Amsterdam University Medical Centers (NL)
- Duke University Hospital (US)
- Ontario Brain Institute (CA)
- Université Grenoble Alpes (FR)
- Vanderbilt University Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1038/s41531-024-00772-5
- Citations
- 89
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 32.85