A novel assay of excess plasma kallikrein-kinin system activation in hereditary angioedema
An ELISA was developed for the specific and quantitative detection of HKa in human plasma to support HAE-C1INH drug development. Improved quantification of the HKa biomarker may facilitate further pathophysiologic insight into HAE-C1INH and other diseases mediated by a dysregulated KKS and may enable the design of highly potent inhibitors targeting this pathway.
Authors
- Ryan Faucette
- Nikolaos Papaioannou (ORCID: https://orcid.org/0000-0002-2516-8497)
- Jon Kenniston
- Janja Cosic
- Kris Kopacz
- Daniel J. Sexton (ORCID: https://orcid.org/0000-0001-9604-5948)
- Salomé Juethner
- Gary Salmon
- Chantal Beauchemin
- Melody Rivera-Hernandez
- Dave Yeung
Institutions
- Charles River Laboratories (United Kingdom) (GB)
- Takeda (United States) (US)
Publication Details
- Journal
- Frontiers in Allergy
- Published
- 2024-09-17
- DOI
- https://doi.org/10.3389/falgy.2024.1436855
- Citations
- 3
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 1.31