Circ_001653 alleviates sepsis associated-acute kidney injury by recruiting BUD13 to regulate KEAP1/NRF2/HO-1 signaling pathway
To summarize, our study is the first to reveal elevated expression of circ_001653 in sepsis-associated AKI, and its downregulation effectively attenuates AKI by reducing apoptosis, inflammation, and oxidative stress. Mechanistically, circ_001653 exerts its effects by recruiting BUD13 to activate the KEAP1/Nrf2/HO-1 signaling pathway. These findings suggest circ_001653 as a potential therapeutic target for the drug development of sepsis-associated AKI.
Authors
- Yingbing Li (ORCID: https://orcid.org/0000-0002-0661-085X)
- Liangliang Zhou (ORCID: https://orcid.org/0000-0001-6148-8212)
- Xinxin Li (ORCID: https://orcid.org/0000-0001-6336-9196)
- Jianjun Chen (ORCID: https://orcid.org/0000-0003-3749-2902)
- Peng Xia (ORCID: https://orcid.org/0000-0001-7448-4464)
- Wei Zhou (ORCID: https://orcid.org/0000-0001-7534-3065)
- Xufeng Wu
Institutions
- Nantong University (CN)
- Yancheng First People's Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1186/s12950-024-00409-7
- Citations
- 11
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.57