Truncated mini LRP1 transports cargo from luminal to basolateral side across the blood brain barrier
Together, the data strongly suggest mLRP1_DIV* as a promising tool for drug delivery into the CNS, as it allows a straight transport of cargo from luminal to abluminal side across an endothelial monolayer and it's release into brain parenchyma in vitro, where it exhibits its intended therapeutic effect.
Authors
- Sascha Weggen (ORCID: https://orcid.org/0000-0002-9800-1145)
- Claus U. Pietrzik (ORCID: https://orcid.org/0000-0002-1202-5489)
- Jakob Körbelin (ORCID: https://orcid.org/0000-0002-5435-7182)
- Gert Fricker (ORCID: https://orcid.org/0000-0003-3894-961X)
- Lelia Wagner (ORCID: https://orcid.org/0000-0002-2201-5583)
- Magdalena Kurtyka (ORCID: https://orcid.org/0000-0002-7608-7670)
- Laura Fritzen (ORCID: https://orcid.org/0000-0002-2094-6368)
- Katharina Vogel
- Katharina Wienken
Institutions
- Universität Hamburg (DE)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- University Cancer Center Hamburg (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1186/s12987-024-00573-1
- Citations
- 5
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.24
Funders
- Alzheimer Forschung Initiative
- European Federation of Pharmaceutical Industries and Associations
- European Commission
- Deutsche Forschungsgemeinschaft
- Universitätsmedizin der Johannes Gutenberg-Universität Mainz