Antibiotic exposure for culture-negative early-onset sepsis in late-preterm and term newborns: an international study
In a study of 757,979 infants born in high-income countries, we report a presumed culture-negative early-onset sepsis incidence of 10.6/1000 livebirths with an associated antibiotic exposure of 77 antibiotic days per 1000 livebirths. This study sheds light on the major contribution of presumed culture-negative early-onset sepsis to early-life antibiotic exposure. Given the diagnostic uncertainty surrounding culture-negative early-onset sepsis, the low mortality rate, and the disproportionate antibiotic exposure associated with this condition, our study emphasizes the importance of targeting culture-negative early-onset sepsis in antimicrobial stewardship programs.
Authors
- Dirk Lehnick (ORCID: https://orcid.org/0000-0003-1836-2811)
- Éric Giannoni (ORCID: https://orcid.org/0000-0003-0897-6529)
- Nicola Laforgia (ORCID: https://orcid.org/0000-0002-4610-1216)
- Martin Stocker (ORCID: https://orcid.org/0000-0002-1461-333X)
- Philipp Agyeman (ORCID: https://orcid.org/0000-0002-8339-5444)
- Alberto Berardi (ORCID: https://orcid.org/0000-0002-3534-7499)
- Salhab el Helou (ORCID: https://orcid.org/0000-0002-1066-8763)
- Viveka Nordberg (ORCID: https://orcid.org/0000-0003-4688-7439)
- Enikő Mózes
- Riccardo Pfister (ORCID: https://orcid.org/0000-0002-7395-0512)
- Giuseppe Latorre (ORCID: https://orcid.org/0000-0003-4636-0880)
- Lars Navér (ORCID: https://orcid.org/0000-0001-6027-0211)
- Tobias Strunk (ORCID: https://orcid.org/0000-0001-7079-2339)
- Judit Mari (ORCID: https://orcid.org/0000-0003-3176-6116)
- Donatienne Lagae
- Gerhard Fusch (ORCID: https://orcid.org/0000-0003-4026-3211)
- Pierre Maton
- Jan Janota (ORCID: https://orcid.org/0000-0002-0684-375X)
- Varvara Dimopoulou
- Nicholas Guerina
- Claus Klingenberg (ORCID: https://orcid.org/0000-0001-6950-1573)
- Joseph M. Bliss (ORCID: https://orcid.org/0000-0002-7425-1895)
- G Maffei
- Joanna Seliga‐Siwecka (ORCID: https://orcid.org/0000-0002-4628-0541)
- Ketil Størdal (ORCID: https://orcid.org/0000-0002-2620-7646)
Institutions
- Semmelweis University (HU)
- University of Bern (CH)
- Oslo University Hospital (NO)
- University Hospital of North Norway (NO)
- Karolinska University Hospital (SE)
- University of Lucerne (CH)
- University of Oslo (NO)
- Charles University (CZ)
- University of Szeged (HU)
- Medical University of Warsaw (PL)
- Brown University (US)
- University Hospital of Bern (CH)
- King Edward Memorial Hospital (AU)
- McMaster Children's Hospital (CA)
- Centre Hospitalier Universitaire Vaudois (CH)
- Karolinska Institutet (SE)
- University of Rochester Medical Center (US)
- Niagara Health System (CA)
- Centre Hospitalier Chrétien (BE)
- Azienda Unita' Sanitaria Locale Di Modena (IT)
- Ospedali Riuniti di Foggia (IT)
- University Hospital in Motol (CZ)
- University Hospital of Geneva (CH)
- Azienda Ospedaliero-Universitaria di Modena (IT)
- University of Teacher Education Lucerne (CH)
- Ospedale “M. Bufalini” di Cesena (IT)
- Azienda USL di Bologna (IT)
- Women & Infants Hospital of Rhode Island (US)
- Centre Hospitalier Interrégional Edith Cavell (BE)
- Ospedale Generale Regionale Francesco Miulli (IT)
- Thomayer University Hospital (CZ)
- University of Bari Aldo Moro (IT)
- UiT The Arctic University of Norway (NO)
- Umeå University (SE)
- UCLouvain (BE)
- University of Lausanne (CH)
Publication Details
- Journal
- Pediatric Research
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1038/s41390-024-03532-6
- Citations
- 18
- Primary Topic
- Neonatal and Maternal Infections
- Type
- article
- Field-Weighted Citation Impact
- 9.77
Funders
- Univerzita Karlova v Praze
- Hamilton Health Sciences
- McMaster University
- Karolinska Institutet
- Warszawski Uniwersytet Medyczny
- Umeå Universitet
- Universitetet i Oslo
- Université de Lausanne
- Uniwersytet Warszawski