Genomic signature for oligometastatic disease in non-small cell lung cancer patients with brain metastases
Elucidation of a genomic signature for extracranial oligometastatic disease derived from non-invasive liquid biopsy appears feasible for NSCLC patients. Patients with this signature exhibited higher rates of early oligoprogression. External validation could lead to a biomarker that has the potential to direct local therapies in oligometastatic patients.
Authors
- Christopher T. Whitlow (ORCID: https://orcid.org/0000-0003-2392-8293)
- Ralph B. D’Agostino (ORCID: https://orcid.org/0000-0002-3550-8395)
- Fei Xing (ORCID: https://orcid.org/0000-0001-6350-0764)
- Jing Su (ORCID: https://orcid.org/0000-0003-4917-6173)
- Michael Farris (ORCID: https://orcid.org/0000-0003-2948-227X)
- Wencheng Li (ORCID: https://orcid.org/0000-0002-4176-8249)
- Thomas Lycan (ORCID: https://orcid.org/0000-0001-9475-1558)
- Jimmy Ruiz (ORCID: https://orcid.org/0000-0002-7242-3315)
- W. Jeffrey Petty (ORCID: https://orcid.org/0000-0002-1553-1838)
- Adrian W. Laxton (ORCID: https://orcid.org/0000-0002-4631-5476)
- Michael D. Chan (ORCID: https://orcid.org/0000-0002-5278-6709)
- Christina K. Cramer (ORCID: https://orcid.org/0000-0001-7618-3921)
- Stephen B. Tatter (ORCID: https://orcid.org/0000-0002-1063-0431)
- Margaret Smith (ORCID: https://orcid.org/0000-0002-3523-7150)
- Mohammed Abdulhaleem (ORCID: https://orcid.org/0000-0002-4429-2178)
- John Hunting (ORCID: https://orcid.org/0000-0002-4066-4763)
- Ariel R. Choi (ORCID: https://orcid.org/0000-0002-0542-6436)
- Jaclyn J. White
- Yuezhu Wang (ORCID: https://orcid.org/0009-0004-9175-2589)
Institutions
- Indiana University School of Medicine
- Wake Forest University (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-09-17
- DOI
- https://doi.org/10.3389/fendo.2024.1364021
- Citations
- 2
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.84