Revealing the association between East Asian oral microbiome and colorectal cancer through Mendelian randomization and multi-omics analysis
This study establishes the critical role of the oral microbiome in colorectal cancer development, identifying specific microbial taxa linked to CRC risk. Single-cell RNA sequencing and drug prediction analyses further elucidate key pathways and potential therapeutics, providing novel insights and personalized treatment strategies for CRC.
Authors
- Yuheng Gu (ORCID: https://orcid.org/0000-0003-0209-3450)
- 敏之 清水
- Xuancheng Zhou (ORCID: https://orcid.org/0009-0003-0700-9382)
- Hao Chi (ORCID: https://orcid.org/0000-0002-7898-2599)
- Jingyi Tang (ORCID: https://orcid.org/0000-0001-6564-557X)
- Hui Luo (ORCID: https://orcid.org/0000-0001-6312-9299)
- Ke Xu (ORCID: https://orcid.org/0000-0001-7222-9523)
- Jinbang Huang
- Shangke Huang
- Jie Liu (ORCID: https://orcid.org/0000-0002-5354-9633)
- Lai Jiang (ORCID: https://orcid.org/0000-0001-7778-2336)
- Haiqing Chen (ORCID: https://orcid.org/0009-0009-4555-9362)
- Shengke Zhang
- Yi‐Ping Fu
- Honghao Luo
- Chenglu Jiang
- Guanhu Yang
Institutions
- Chongqing University (CN)
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Ohio University (US)
- Nanchong Central Hospital (CN)
- First People's Hospital of Chongqing (CN)
- Dazhou Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-09-17
- DOI
- https://doi.org/10.3389/fcimb.2024.1452392
- Citations
- 21
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 5.99