A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury
Our findings supported PTOA drug intervention studies, including situations where there is low risk of disease, no expected benefit of treatment, and frequent treatment administration. PJDs appeared less risk-averse than HCP/Rs. This work reinforces the benefits of consensus and involvement work in the co-creation of PTOA drug trial design. Involvement of key stakeholders, such as PJDs with different risks of OA and regulatory representatives, are critical for trial design success.
Authors
- Martyn Snow (ORCID: https://orcid.org/0000-0002-1366-109X)
- Karina T. Wright (ORCID: https://orcid.org/0000-0001-8842-5908)
- Andrew W. McCaskie (ORCID: https://orcid.org/0000-0001-6476-0832)
- Catherine Lowe (ORCID: https://orcid.org/0000-0002-1924-2267)
- D.J. Mason (ORCID: https://orcid.org/0000-0003-4926-3365)
- Fiona E. Watt (ORCID: https://orcid.org/0000-0002-6066-7590)
- Sophie Gilbert (ORCID: https://orcid.org/0000-0001-9828-132X)
- Raneem Kalsoum (ORCID: https://orcid.org/0009-0002-7925-171X)
- G.R. Bruce
Institutions
- University of Hertfordshire (GB)
- Imperial College Healthcare NHS Trust (GB)
- University of Cambridge (GB)
- Royal Orthopaedic Hospital (GB)
- Robert Jones and Agnes Hunt Orthopaedic Hospital (GB)
- University of Oxford (GB)
- Arthritis UK (GB)
- Addenbrooke's Hospital (GB)
- Imperial College London (GB)
- Keele University (GB)
- Cardiff University (GB)
Publication Details
- Journal
- Bone and Joint Research
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1302/2046-3758.139.bjr-2024-0109
- Citations
- 2
- Primary Topic
- Knee injuries and reconstruction techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Orthopaedic Research Society
- British Orthopaedic Research Society
- Versus Arthritis
- Medical Research Council