Collaborative weighting in federated graph neural networks for disease classification with the human-in-the-loop

The authors introduce a novel framework that integrates federated learning with Graph Neural Networks (GNNs) to classify diseases, incorporating Human-in-the-Loop methodologies. This advanced framework innovatively employs collaborative voting mechanisms on subgraphs within a Protein-Protein Interaction (PPI) network, situated in a federated ensemble-based deep learning context. This methodological approach marks a significant stride in the development of explainable and privacy-aware Artificial Intelligence, significantly contributing to the progression of personalized digital medicine in a responsible and transparent manner.