Shenqi Sanjie Granules induce Hmox1-mediated ferroptosis to inhibit colorectal cancer
Collectively, our findings indicate that the administration of SSG has the potential to inhibit CRC both <i>in vitro</i> and <i>in vivo</i>. The mechanism by which this compound preparation exerts its action is, at least partly, the induction of ferroptosis through upregulating Hmox-1 by its three active ingredients Quercetin, Luteolin and Kaempferol.
Authors
- Haiming Dai (ORCID: https://orcid.org/0000-0002-0484-7407)
- Jianke Yang (ORCID: https://orcid.org/0000-0002-1373-0382)
- Wenbo Ji (ORCID: https://orcid.org/0000-0001-7803-7880)
- Shasha Yang (ORCID: https://orcid.org/0000-0002-6646-5332)
- Jiguang Gao
- Qianwen Cui
- Weihua Hu (ORCID: https://orcid.org/0000-0001-6278-9551)
- Xiaohui Xu
- Lei Hu (ORCID: https://orcid.org/0000-0002-1477-4096)
- Yü Liu (ORCID: https://orcid.org/0000-0003-2211-3535)
- Shengli Ma (ORCID: https://orcid.org/0000-0002-8327-292X)
- Meng Chen (ORCID: https://orcid.org/0009-0000-2807-9257)
Institutions
- Wannan Medical College (CN)
- University of Science and Technology of China (CN)
- Chinese Academy of Sciences (CN)
- Hefei Institutes of Physical Science (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38021
- Citations
- 8
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.35
Funders
- Wannan Medical College