Binary proton therapy of Ehrlich carcinoma using targeted gold nanoparticles
Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing the proton therapy with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG nanoparticles at concentrations above 25 mg/L and 4 Gy proton dose caused complete death of EMT6/P cells in vitro. Binary proton therapy using targeted Au-PEG-FA nanoparticles caused an 80% tumor growth inhibition effect in vivo. The use of targeted gold nanoparticles is promising for enhancing the proton irradiation effect on tumor cells and requires further research to increase the therapeutic index of the approach.
Authors
- Gleb V. Tikhonowski (ORCID: https://orcid.org/0000-0003-4998-1631)
- K. E. Shpakova (ORCID: https://orcid.org/0000-0003-0246-1794)
- D. S. Petrunya (ORCID: https://orcid.org/0009-0004-9075-5622)
- I. N. Zavestovskaya (ORCID: https://orcid.org/0000-0002-2690-6797)
- Polina A. Kotelnikova (ORCID: https://orcid.org/0000-0001-6570-8147)
- Ivan V. Zelepukin (ORCID: https://orcid.org/0000-0003-0209-2116)
- Anton A. Popov (ORCID: https://orcid.org/0000-0001-8902-0371)
- K. A. Nikolaev
- Danil D. Kolmanovich (ORCID: https://orcid.org/0000-0003-3391-7889)
- S. N. Koryakin
- M. S. Savinov (ORCID: https://orcid.org/0009-0009-0996-3165)
- V. A. Rybachuk
- A. S. Filimonov
- A. V. Kabashin
- М. В. Филимонова (ORCID: https://orcid.org/0000-0002-9690-4746)
- А. А. Lipengolts (ORCID: https://orcid.org/0000-0002-5631-9016)
- O. V. Soldatova (ORCID: https://orcid.org/0000-0002-1178-3560)
- A. O. Kosachenko (ORCID: https://orcid.org/0000-0003-2173-388X)
- Grigory A. Demyashkin (ORCID: https://orcid.org/0000-0001-8447-2600)
- S. M. Deyev
- A. A. Shitova
- Anton L. Popov
Institutions
- P.N. Lebedev Physical Institute of the Russian Academy of Sciences (RU)
- Aix-Marseille Université (FR)
- Institute of Theoretical and Experimental Biophysics (RU)
- Institute of Bioorganic Chemistry (RU)
- Ministry of Health of the Russian Federation (RU)
- Medical Radiological Research Center (RU)
- National Research Nuclear University MEPhI (RU)
Publication Details
- Journal
- Доклады Российской академии наук Науки о жизни
- Published
- 2024-09-15
- DOI
- https://doi.org/10.31857/s2686738924030104
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00