Case report: Personalized triple phage-antibiotic combination therapy to rescue necrotizing fasciitis caused by Panton-Valentine leukocidin-producing MRSA in a 12-year-old boy
Maximal standard-of-care (SOC) management could not stop the life-threatening progression of a necrotizing fasciitis induced by Panton-Valentine Leukocidin-producing Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) in a 12-year-old boy. Multi-route phage therapy was initiated along with antibiotics against <i>Staphylococcus aureus, Pseudomonas aeruginosa</i> and <i>Stenotrophomonas maltophilia</i>, eventually leading to full recovery with no reported adverse events.
Authors
- Julien De Greef (ORCID: https://orcid.org/0000-0003-0200-1237)
- Emilien Derycke
- Olga Chatzis (ORCID: https://orcid.org/0000-0002-3667-9444)
- Brieuc Van Nieuwenhuyse (ORCID: https://orcid.org/0000-0002-6563-1394)
- Olivier Cornu
- Laurent Houtekie
- Leïla Belkhir (ORCID: https://orcid.org/0000-0002-1701-7584)
- Sarah Djebara
- Hector Rodriguez‐Villalobos (ORCID: https://orcid.org/0000-0003-3041-1591)
- Pierre‐Louis Docquier (ORCID: https://orcid.org/0000-0003-0309-3970)
- Jean Cyr Yombi (ORCID: https://orcid.org/0000-0001-8424-2346)
- Thierry Detaille (ORCID: https://orcid.org/0000-0003-0372-578X)
- Cécile Boulanger (ORCID: https://orcid.org/0000-0002-2969-6131)
- Renaud Menten (ORCID: https://orcid.org/0000-0002-0982-8598)
- Jean‐Paul Pirnay (ORCID: https://orcid.org/0000-0002-6863-5219)
- Astrid Haenecour
- Alexia Verroken (ORCID: https://orcid.org/0000-0001-5486-964X)
- Johann Griselain
- Dimitri Van der Linden (ORCID: https://orcid.org/0000-0002-2696-4559)
- Stephan Clément de Clety (ORCID: https://orcid.org/0000-0002-1271-6650)
- Mathilde Balcaen
- Maya Merabishvili
- Audrey Lentini
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- Queen Astrid Military Hospital (BE)
- de Duve Institute (BE)
- UCLouvain (BE)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2024-09-17
- DOI
- https://doi.org/10.3389/fcimb.2024.1354681
- Citations
- 9
- Primary Topic
- Streptococcal Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.89
Funders
- KU Leuven