Combinatorial protection of cochlear hair cells: not too little but not too much
The results support the hypothesis that targeting multiple cellular damage or survival pathways provides more an effective hair cell protection approach. The results help to identify critical interactions among the cellular processes that operate in gentamicin ototoxicity. They also suggest that inhibiting too many biological processes impairs functions critical to HC survival, resulting in decreased protection.
Authors
- Allen F. Ryan (ORCID: https://orcid.org/0000-0001-9894-8083)
- Arwa Kurabi (ORCID: https://orcid.org/0000-0001-5765-9496)
- Eun Jung Lee (ORCID: https://orcid.org/0000-0003-2257-9319)
- Kwang Pak
Institutions
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- Jeonbuk National University (KR)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2024-09-17
- DOI
- https://doi.org/10.3389/fncel.2024.1458720
- Citations
- 1
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.36