CCL5 is essential for axonogenesis and neuronal restoration after brain injury
CCL5 plays a critical role in starting the intrinsic neuronal regeneration system following TBI, which includes growth cone formation, axonogenesis and synaptogensis, remyelination, and the subsequent proper wiring of cortical circuits. Our study underscores the potential of CCL5 as a robust therapeutic stratagem in treating axonal injury and degeneration during the chronic phase after mild brain injury.
Authors
- Thierry Pierre Robert Burnouf (ORCID: https://orcid.org/0000-0002-0507-9243)
- Man-Hau Ho (ORCID: https://orcid.org/0000-0001-9488-1168)
- Szu‐Yi Chou (ORCID: https://orcid.org/0000-0002-4387-749X)
- Yung‐Hsiao Chiang (ORCID: https://orcid.org/0000-0002-8426-4016)
- Yih‐Jeng Tsai (ORCID: https://orcid.org/0000-0002-5608-814X)
- Barry J. Hoffer (ORCID: https://orcid.org/0000-0002-1122-9025)
- Yun Wang (ORCID: https://orcid.org/0000-0001-7983-5905)
- Chia-Yen Chen (ORCID: https://orcid.org/0000-0001-6417-6994)
- A. Yang (ORCID: https://orcid.org/0009-0002-0451-5223)
Institutions
- Fu Jen Catholic University (TW)
- National Institutes of Health (US)
- National Health Research Institutes (TW)
- University Hospitals of Cleveland (US)
- Taipei Medical University Hospital (TW)
- University School (US)
- Memorial Hospital (US)
- Taipei Medical University (TW)
- Case Western Reserve University (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1186/s12929-024-01083-w
- Citations
- 19
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 7.01
Funders
- Ministry of Education
- Shin Kong Wu Ho-Su Memorial Hospital
- Ministry of Science and Technology, Taiwan