ARMCX1 inhibits lung adenocarcinoma progression by recruiting FBXW7 for c-Myc degradation
ARMCX1 inhibits LUAD cell proliferation and metastasis by interacting with c-Myc and enhancing its ubiquitination and degradation. Consequently, it can act as a tumor suppressor in this disease. These results suggest that ARMCX1 is a potential target in the treatment of LUAD.
Authors
- Yanli Tong (ORCID: https://orcid.org/0000-0001-5283-4689)
- Yilin Wu (ORCID: https://orcid.org/0000-0002-3549-6259)
- Enqing Zhuo
- Zhe Hu (ORCID: https://orcid.org/0000-0001-6764-5610)
- Xiaoou Sun (ORCID: https://orcid.org/0000-0002-0651-661X)
- Houkuang Qiu
Institutions
- Guangdong University of Technology (CN)
- Jinan University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1186/s13062-024-00532-8
- Citations
- 3
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Southern Medical University
- Guangzhou Municipal Science and Technology Project