Proteasome inhibition enhances the anti-leukemic efficacy of chimeric antigen receptor (CAR) expressing NK cells against acute myeloid leukemia
PIs enhance the anti-leukemic efficacy of CAR-expressing allogeneic NK cells against AML in vitro and in vivo, warranting further exploration of this combinatorial treatment within early phase clinical trials.
Authors
- Brigitte Neuber
- David Sedloev
- Michael Schmitt (ORCID: https://orcid.org/0000-0002-1579-1509)
- Maike Janssen (ORCID: https://orcid.org/0000-0001-9899-1022)
- Carsten Müller‐Tidow (ORCID: https://orcid.org/0000-0002-7166-5232)
- Nicola Schanda
- Yao Hao (ORCID: https://orcid.org/0000-0002-5277-7271)
- Simon Raffel (ORCID: https://orcid.org/0000-0003-4671-1097)
- Julia M. Unglaub (ORCID: https://orcid.org/0000-0002-3577-5493)
- Tim Sauer (ORCID: https://orcid.org/0000-0001-5412-324X)
- Eleni Besiridou
- Yi Liu (ORCID: https://orcid.org/0000-0002-4961-2660)
- Qian Chen (ORCID: https://orcid.org/0000-0002-1487-5479)
- Anita Schmitt
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
Publication Details
- Journal
- Journal of Hematology & Oncology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1186/s13045-024-01604-y
- Citations
- 12
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.39
Funders
- Universitätsklinikum Heidelberg