Changes of CD8+CD28- Tregs and Gamma-Delta-T-cells in a Neonate with Intrauterine Cytomegalovirus Infection: A Case Report
Despite the alleviation of clinical symptoms, developmental delay in later life remains inevitable in this intrauterine cCMV neonate. CD8<sup>+</sup>CD28<sup>-</sup> Tregs and Vδ1 and Vδ2 T cells secreting perforin and granzyme B may be involved in congenital CMV infection, although this hypothesis requires validation in a larger study. This report may contribute to our understanding of the effect of current treatment and the immune status of intrauterine cCMV-infected neonates.
Authors
- Ping Zhou
- Tingyan Xie
- Fan Jiang
- Xian Chen
- Zhenchao Jin
- Quan Tang
Institutions
- Shenzhen Bao'an District People's Hospital (CN)
- Shenzhen Children's Hospital (CN)
Publication Details
- Journal
- BMC Pediatrics
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1186/s12887-024-05051-z
- Citations
- 2
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- National Natural Science Foundation of China