The Omega‐6 Lipid pathway shift is associated with neutrophil influx and structural lung damage in early cystic fibrosis lung disease
Our data provide more insight into the lung lipidome of infants with CF, and show that a shift from LA derivatives to AA derivatives in BALF associates with early CF lung disease progression.
Authors
- Lisa J. M. Slimmen
- Wendy WJ Unger
- Martin Giera (ORCID: https://orcid.org/0000-0003-1684-1894)
- Hettie M. Janssens (ORCID: https://orcid.org/0000-0002-2210-9176)
- Jelle Y. Broos
- Silvia Estevão
- Gijs Kooij (ORCID: https://orcid.org/0000-0002-9488-2918)
- B. Manaï
Institutions
- Leiden University (NL)
- Netherlands Metabolomics Centre (NL)
- Amsterdam Neuroscience (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Clinical & Translational Immunology
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/cti2.70000
- Citations
- 3
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- Cystic Fibrosis Foundation
- Nederlandse Cystic Fibrosis Stichting
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- National Institutes of Health