High Mechanical Conditioning by Tumor Extracellular Matrix Stiffness Is a Predictive Biomarker for Antifibrotic Therapy in HER2-Negative Breast Cancer
High MeCo is predictive of poor outcomes in HER2-negative early breast cancer, although this risk can be mitigated by nintedanib, which is able to specifically reduce MeCo.
Authors
- Miguel Quintela-Fandiño (ORCID: https://orcid.org/0000-0003-1648-1964)
- Ghassan Mouneimne (ORCID: https://orcid.org/0000-0001-8103-4701)
- Denise J. Roe (ORCID: https://orcid.org/0000-0001-6989-6579)
- Begoña Bermejo (ORCID: https://orcid.org/0000-0001-7773-5994)
- Adam Watson (ORCID: https://orcid.org/0000-0002-8871-9479)
- Gemma Viñas (ORCID: https://orcid.org/0000-0002-0459-573X)
- Sònia Pernas (ORCID: https://orcid.org/0000-0002-1485-5080)
- José Á. García-Sáenz (ORCID: https://orcid.org/0000-0001-6880-0301)
- Antonio Llombart‐Cussac (ORCID: https://orcid.org/0000-0003-4515-8293)
- Emilio Alba (ORCID: https://orcid.org/0000-0002-3364-2603)
- Fernando Moreno (ORCID: https://orcid.org/0000-0001-8933-0687)
- Luís Manso (ORCID: https://orcid.org/0000-0002-1683-550X)
- Silvana Mourón (ORCID: https://orcid.org/0000-0001-6287-8001)
- Rámón Colomer (ORCID: https://orcid.org/0000-0002-6393-3444)
- Javier Cortés (ORCID: https://orcid.org/0000-0001-7623-1583)
- Esther Zamora (ORCID: https://orcid.org/0000-0002-2233-367X)
- María J. Bueno (ORCID: https://orcid.org/0000-0002-3910-0637)
- Cristina Tebar (ORCID: https://orcid.org/0000-0001-5012-0615)
- Encarna Adrover (ORCID: https://orcid.org/0000-0001-8676-8560)
- Noelia Martínez-Jáñez (ORCID: https://orcid.org/0000-0002-0436-0906)
- Raquel Andrés (ORCID: https://orcid.org/0000-0003-4315-415X)
- Desirée Jiménez
- Adam Grant
Institutions
- University of Arizona (US)
- Catalan Institute for Water Research (ES)
- Arizona Science Center (US)
- Hospital Clínico San Carlos (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- 490 BioTech (United States) (US)
- Spanish National Cancer Research Centre (ES)
- Hospital Clínico Universitario de Valencia (ES)
- Hospital Universitario 12 De Octubre (ES)
- MedSIR (Spain) (ES)
- Institut Català d'Oncologia (ES)
- Hospital Arnau de Vilanova (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital Universitario de La Princesa (ES)
- Hospital Clínico Universitario Lozano Blesa (ES)
- Centro de Investigación del Cáncer (ES)
- CS Diagnostics (DE)
- Hospital Universitario de Fuenlabrada (ES)
- Hospital Universitari de Girona Doctor Josep Trueta (ES)
- Complejo Hospitalario Universitario de Albacete (ES)
- International Breast Cancer Study Group (CH)
- Hospital Clínico Universitario Virgen de la Victoria (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Vall d'Hebron Institute of Oncology (ES)
- Universidad Autónoma de Madrid (ES)
- Universidad Europea de Madrid (ES)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1518
- Citations
- 12
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 3.91
Funders
- Mary Kay Foundation
- Instituto de Salud Carlos III