Blood metabolites, neurocognition and psychiatric disorders: a Mendelian randomization analysis to investigate causal pathways
Our results provide genetic evidence that acetylornithine protects against bipolar disorder through neurocognitive abilities, while butyrylcarnitine has an adverse effect on schizophrenia through neurocognition. These findings may provide insight into interventions at the metabolic level for risk of neurocognitive and related disorders.
Authors
- Jing Guo (ORCID: https://orcid.org/0000-0003-3662-7254)
- Yuanyuan Duan (ORCID: https://orcid.org/0000-0002-2886-210X)
- Shi-Hao Tang
- Ke Yu (ORCID: https://orcid.org/0009-0000-9449-9006)
- Shan‐Shan Dong (ORCID: https://orcid.org/0000-0001-6976-4576)
- Shi Yao (ORCID: https://orcid.org/0000-0002-4574-8106)
- Yan Guo (ORCID: https://orcid.org/0000-0002-7364-2392)
- Tie‐Lin Yang (ORCID: https://orcid.org/0000-0001-7062-3025)
- Jiahao Wang (ORCID: https://orcid.org/0000-0002-4268-8021)
- Ji-Zhou Han
- Congcong Liu (ORCID: https://orcid.org/0000-0003-3949-4194)
- Ping Yang (ORCID: https://orcid.org/0000-0002-0321-1132)
- Kun Zhang (ORCID: https://orcid.org/0000-0003-0054-2099)
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- Guangdong Medical College (CN)
- Hunan Institute of Mental Health (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Translational Psychiatry
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1038/s41398-024-03095-4
- Citations
- 4
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.20
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Health and Family Planning Commission of Hunan Province
- Fundamental Research Funds for the Central Universities