Monnieriside A from <i>Evolvulus linarioides</i> promotes antinociceptive effects in models of inflammatory and postoperative pain in male mice
Monnieriside A (MoA) is a chromone isolated from <i>Evolvulus linarioides</i>. This study investigated the antinociceptive potential of MoA in mice. MoA (0.01-100 mg/kg, i.p.) inhibited nociception in the inflammatory phase of the formalin test without causing motor impairment. MoA (0.1-100 mg/kg, i.p.) also reduced hindpaw mechanical allodynia caused by either intraplantar injection of Complete Freund's Adjuvant (CFA) or surgical paw incision to simulate postoperative pain. Postoperative antinociception was accompanied by reduced IL-1β levels in the incised paw, assessed by ELISA. The antinociceptive action of MoA (100 mg/kg, i.p.) was preserved in IL-10 knockout mice submitted to paw incision, indicating that IL-10 is not essential to the antinociceptive effect. Interestingly, MoA (100 mg/kg, i.p.) increased the expression of TGF-β in IL-10 knockout mice, which could be a compensation mechanism leading to an antinociceptive effect in the absence of IL-10.
Authors
- Luı́za Carolina França Opretzka (ORCID: https://orcid.org/0000-0002-7941-6855)
- Diego Francisco de Agnelo-Silva (ORCID: https://orcid.org/0000-0002-2560-9344)
- Lucas Silva Abreu (ORCID: https://orcid.org/0000-0001-5620-8095)
- Milena Botelho Pereira Soares (ORCID: https://orcid.org/0000-0001-7549-2992)
- Cristiane Flora Villarreal (ORCID: https://orcid.org/0000-0002-0113-7864)
- Marcelo Sobral da Silva (ORCID: https://orcid.org/0000-0003-3451-8468)
- Max Denisson Maurı́cio Viana (ORCID: https://orcid.org/0000-0002-1650-4460)
- Laiane C. O. Pereira (ORCID: https://orcid.org/0009-0008-3915-8688)
- Pedro Santana Sales Lauria (ORCID: https://orcid.org/0000-0002-6986-8444)
- Josean Fechine Tavares (ORCID: https://orcid.org/0000-0003-0293-2605)
Institutions
- Universidade Federal da Bahia (BR)
- Serviço Nacional de Aprendizagem Industrial (BR)
- Universidade Federal da Paraíba (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Natural Product Research
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1080/14786419.2024.2401497
- Citations
- 1
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fundação de Amparo à Pesquisa do Estado da Bahia