Asymmetric Transfer Hydrogenation of <i>gem</i>-Difluorocyclopropenyl Ketones: The Synthesis and Functionalization of Enantioenriched <i>cis gem</i>-Difluorocyclopropyl Ketones
The asymmetric transfer hydrogenation of <i>gem</i>-difluorocyclopropenyl ketones, catalyzed by a Noyori-Ikariya ruthenium complex, was developed to access substituted optically enriched <i>cis</i>-disubstituted <i>gem</i>-difluorocyclopropyl ketones, and the value of these latter building blocks was illustrated by the synthesis of heterocycles fused to the difluorocyclopropyl moiety.
Authors
- Geoffrey Gontard (ORCID: https://orcid.org/0000-0002-4099-5423)
- Olivier Charron
- Phannarath Phansavath
- Christophe Meyer (ORCID: https://orcid.org/0000-0003-3420-5584)
- Virginie Ratovelomanana-Vidal
- Marharyta Kosiuha
Institutions
- Centre National de la Recherche Scientifique (FR)
- Chimie ParisTech - PSL (FR)
- Université Paris Sciences et Lettres (FR)
- Sorbonne Université (FR)
- Institut Parisien de Chimie Moléculaire (FR)
- ESPCI Paris (FR)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1021/acs.joc.4c01497
- Citations
- 2
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Agence Nationale de la Recherche