Artemisinin conferred cytoprotection to human retinal pigment epithelial cells exposed to amiodarone-induced oxidative insult by activating the CaMKK2/AMPK/Nrf2 pathway
Artemisinin protected RPE cells from amiodarone-induced damage via the CaMKK2/AMPK/Nrf2 pathway. The in vivo experiments in mice confirmed its efficacy in preventing retinal injury caused by amiodarone. These results suggest that an artemisinin-based eye formulation could be repurposed for treating amiodarone-induced ocular toxicity.
Authors
- Philip Lazarovici (ORCID: https://orcid.org/0000-0003-3650-4721)
- Qin Li (ORCID: https://orcid.org/0000-0002-9797-2636)
- Wenhua Zheng (ORCID: https://orcid.org/0000-0001-9767-4295)
- Chao Yang (ORCID: https://orcid.org/0000-0002-2502-3861)
- Xia Zhao (ORCID: https://orcid.org/0000-0002-2379-9447)
- Wenshu Zhou (ORCID: https://orcid.org/0009-0004-8015-6992)
Institutions
- Hebrew University of Jerusalem (IL)
- University of Macau (MO)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1186/s12967-024-05593-x
- Citations
- 9
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- United Mitochondrial Disease Foundation
- National Natural Science Foundation of China
- Hebrew University of Jerusalem
- Universidade de Macau
- Fundo para o Desenvolvimento das Ciências e da Tecnologia
- Guangdong Science and Technology Department
- Graduate and Professional Student Council, University of Arizona
- Basic and Applied Basic Research Foundation of Guangdong Province