Predictive and Dynamic Signature for Antiangiogenics in Combination with a PD1 Inhibitor in Soft-Tissue Sarcoma: Correlative Studies Linked to the IMMUNOSARC Trial
Treatment with sunitinib and nivolumab inflamed the sarcoma microenvironment, increasing CD8+ T-cell density and the expression of several genes/proteins with relevance in the response to PD1 inhibitors. A molecular signature identified two groups of patients with distinct PFS for the combination of antiangiogenics plus PD1 inhibitor therapy.
Authors
- Antonio M. Gutierrez (ORCID: https://orcid.org/0000-0001-9062-077X)
- Victor Encinas-Tobajas (ORCID: https://orcid.org/0000-0002-8785-4898)
- Claudia Valverde (ORCID: https://orcid.org/0000-0003-4107-8616)
- David S. Moura (ORCID: https://orcid.org/0000-0002-6514-2419)
- Nadia Hindi (ORCID: https://orcid.org/0000-0002-5864-762X)
- Marta Ramírez-Calvo (ORCID: https://orcid.org/0000-0002-7179-5360)
- José L. Mondaza-Hernández (ORCID: https://orcid.org/0000-0002-5642-3796)
- Javier Martínez‐Trufero (ORCID: https://orcid.org/0000-0002-0997-2573)
- Javier Martín‐Broto (ORCID: https://orcid.org/0000-0001-7350-6916)
- Marta Martín‐Ruíz (ORCID: https://orcid.org/0000-0003-0711-8979)
- Dario Sangiolo (ORCID: https://orcid.org/0000-0002-7163-7071)
- Giovanni Grignani (ORCID: https://orcid.org/0000-0001-5515-569X)
- Davide di Lernia (ORCID: https://orcid.org/0000-0001-8893-8471)
- Silvia Stacchiotti (ORCID: https://orcid.org/0000-0002-1742-8666)
- Iva Benešová (ORCID: https://orcid.org/0000-0003-4886-4214)
- Zuzana Střížová (ORCID: https://orcid.org/0000-0003-4976-9534)
- José Antonio López‐Guerrero (ORCID: https://orcid.org/0000-0002-7369-8388)
- José A. López-Martín (ORCID: https://orcid.org/0000-0001-7530-3207)
- Serena Lacerenza (ORCID: https://orcid.org/0000-0003-2475-0706)
- Andrés Redondo (ORCID: https://orcid.org/0000-0002-7257-5642)
- Antonio López–Pousa (ORCID: https://orcid.org/0000-0003-1066-3951)
- Jesús M. López Martí (ORCID: https://orcid.org/0000-0002-3006-1360)
- Carlos de Andrea
Institutions
- Hebron University (PS)
- Charles University (CZ)
- Hospital Universitario La Paz (ES)
- Hospital de Sant Pau (ES)
- Valencia Catholic University Saint Vincent Martyr (ES)
- Research Institute Hospital 12 de Octubre (ES)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- 5T Torino (Italy) (IT)
- University Hospital in Motol (CZ)
- Valencian Infertility Institute (ES)
- Fundación Instituto Valenciano de Oncología (ES)
- Hospital Universitario Miguel Servet (ES)
- Health Research Institute of the Balearic Islands (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Clinica Universidad de Navarra (ES)
- Comunidad de Madrid (ES)
- Hospital Universitario Son Espases (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- University of Turin (IT)
- Universidad Autónoma de Madrid (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1782
- Citations
- 3
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- Sarcoma Foundation of America
- Horizon 2020 Framework Programme
- Instituto de Salud Carlos III