Description of bone health in adolescents and young persons with Klinefelter syndrome – results from a pilot study
BHI SDS and BMD z-scores were lower than expected in young individuals with KS despite age-appropriate bone turnover markers and no apparent pathology in osteoclast differentiation. The cause of the early-onset bone phenotype requires further investigation.
Authors
- Jakob Höppner (ORCID: https://orcid.org/0000-0001-9908-2066)
- Kathrin Sinningen (ORCID: https://orcid.org/0000-0002-4902-3954)
- Julia Spiekermann (ORCID: https://orcid.org/0000-0002-9461-7727)
- Heide Siggelkow (ORCID: https://orcid.org/0000-0002-8366-8625)
- Corinna Grasemann (ORCID: https://orcid.org/0000-0003-1793-4603)
- Cordula Kiewert
- Beatrice Hanusch (ORCID: https://orcid.org/0000-0003-3495-4614)
- Eliena Ibnukhsein
Institutions
- Witten/Herdecke University (DE)
- University Hospitals of the Ruhr-University of Bochum (DE)
- Universitätsmedizin Göttingen (DE)
- Essen University Hospital (DE)
- St. Josef-Hospital (DE)
- Katholisches Klinikum Bochum (DE)
- University of Duisburg-Essen (DE)
- University of Göttingen (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Molecular and Cellular Pediatrics
- Published
- 2024-09-17
- DOI
- https://doi.org/10.1186/s40348-024-00182-w
- Citations
- 2
- Primary Topic
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 1.10