Metabolic modulation to improve MSC expansion and therapeutic potential for articular cartilage repair
Our results suggest an improved MSC manufacturing process that can enhance chondrogenic potential by targeting MSC metabolism and integrating process analytic tools during expansion.
Authors
- Zheng Yang (ORCID: https://orcid.org/0000-0003-4275-0590)
- Laurie A. Boyer (ORCID: https://orcid.org/0000-0003-3491-4962)
- Rashidah Othman
- Daniel N. Roxby
- Lisa Tucker‐Kellogg (ORCID: https://orcid.org/0000-0002-1301-7069)
- Jongyoon Han (ORCID: https://orcid.org/0000-0001-7215-1439)
- Vinitha Denslin
- Ching Ann Tee (ORCID: https://orcid.org/0000-0002-1186-8580)
- Kiseer Sideeq Bhat
Institutions
- Vassar College (US)
- University of Kashmir (IN)
- National University of Singapore (SG)
- Duke-NUS Medical School (SG)
- National University Health System (SG)
- Singapore-MIT Alliance for Research and Technology (SG)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1186/s13287-024-03923-w
- Citations
- 11
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.17
Funders
- Massachusetts Institute of Technology