Environmental toxicants modulate disease severity in pediatric metabolic dysfunction‐associated steatohepatitis
Significant negative PFAS/PBDE mixture effect and odds of MASH were dominated by PHFXS. Several metabolites are significantly associated with MASH which inform mechanistic pathways and could drive key therapeutic and diagnostic strategies in children.
Authors
- Ann Scheimann (ORCID: https://orcid.org/0000-0001-5615-7662)
- Miriam B. Vos (ORCID: https://orcid.org/0000-0002-0817-7068)
- Chris Gennings (ORCID: https://orcid.org/0000-0002-6058-5907)
- Ajay K. Jain (ORCID: https://orcid.org/0000-0002-9420-5722)
- Stavra A. Xanthakos (ORCID: https://orcid.org/0000-0001-9179-005X)
- Jean Pappas Molleston (ORCID: https://orcid.org/0000-0002-8708-0298)
- Mark Fishbein (ORCID: https://orcid.org/0000-0002-3597-3748)
- Karen F. Murray (ORCID: https://orcid.org/0000-0003-2662-640X)
- Stefanie A. Busgang (ORCID: https://orcid.org/0000-0003-1397-2055)
- Cynthia A. Behling (ORCID: https://orcid.org/0000-0001-7016-2636)
- Brent A. Neuschwander‐Tetri (ORCID: https://orcid.org/0000-0002-8520-7398)
- Philip J. Rosenthal (ORCID: https://orcid.org/0000-0002-7953-7622)
- Jeffrey B. Schwimmer (ORCID: https://orcid.org/0000-0001-8538-2877)
- Danielle Carpenter (ORCID: https://orcid.org/0000-0001-7203-7046)
- Katherine P. Yates (ORCID: https://orcid.org/0000-0001-6138-2194)
- James Tonasia
Institutions
- Northwestern University (US)
- Cincinnati Children's Hospital Medical Center (US)
- Cleveland Clinic (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of California, San Francisco (US)
- Johns Hopkins Medicine (US)
- Riley Hospital for Children (US)
- University of California San Diego (US)
- Rady Children's Hospital-San Diego (US)
- Pacific Rim Engineering (United States) (US)
- UCSF Benioff Children's Hospital (US)
- Children's Healthcare of Atlanta (US)
- Indiana University School of Medicine
- Saint Louis University (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Cincinnati (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of Pediatric Gastroenterology and Nutrition
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1002/jpn3.12346
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Saint Louis University
- National Institutes of Health
- Liver Center, Saint Louis University
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Advancing Translational Sciences