GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression
This study identifies GDF-15 as a novel biomarker of EHE aggressiveness and underscores the superior efficacy of sirolimus compared with doxorubicin in our experimental models. The observed inhibition of GDF-15 release by sirolimus suggests its potential as a biomarker for monitoring the drug's activity in patients.
Authors
- Silvia Brich (ORCID: https://orcid.org/0000-0002-6359-1712)
- Paolo Verderio (ORCID: https://orcid.org/0000-0002-9231-1281)
- Paolo G. Casali (ORCID: https://orcid.org/0000-0003-4056-8023)
- Alessandra Merlini (ORCID: https://orcid.org/0000-0002-5280-1411)
- William D. Tap (ORCID: https://orcid.org/0000-0001-7779-2796)
- Paul H. Huang (ORCID: https://orcid.org/0000-0003-3972-5087)
- Alessia Beretta (ORCID: https://orcid.org/0009-0004-6973-4165)
- Paola Collini (ORCID: https://orcid.org/0000-0002-6158-210X)
- Robin L. Jones (ORCID: https://orcid.org/0000-0003-4173-3844)
- Mara Lecchi (ORCID: https://orcid.org/0000-0002-0405-9339)
- Anna Maria Frezza (ORCID: https://orcid.org/0000-0003-2335-7224)
- Silvia Stacchiotti (ORCID: https://orcid.org/0000-0002-1742-8666)
- Matilde Ingrosso (ORCID: https://orcid.org/0009-0002-7053-4684)
- Marta Barisella (ORCID: https://orcid.org/0000-0001-9728-3120)
- Stefano Percio (ORCID: https://orcid.org/0000-0002-9362-2639)
- Monica Tortoreto (ORCID: https://orcid.org/0000-0002-1399-9197)
- Claudia Giani (ORCID: https://orcid.org/0000-0001-8630-4037)
- Alessandro Gronchi (ORCID: https://orcid.org/0000-0002-4703-3534)
- Gian Paolo Dagrada (ORCID: https://orcid.org/0000-0002-6743-1935)
- Silvia Martini (ORCID: https://orcid.org/0000-0001-9314-5230)
- Valentina Zuco (ORCID: https://orcid.org/0000-0001-7882-9095)
- Nadia Zaffaroni (ORCID: https://orcid.org/0000-0002-4669-0890)
- Hugh Leonard (ORCID: https://orcid.org/0000-0002-9379-9848)
- Carlo Morosi (ORCID: https://orcid.org/0000-0003-4940-2185)
- Sandro Pasquali (ORCID: https://orcid.org/0000-0003-4815-6293)
- Andrew Jenks
Institutions
- Royal Marsden NHS Foundation Trust (GB)
- Memorial Sloan Kettering Cancer Center (US)
- Institute of Cancer Research (GB)
- Department of Medical Sciences (BY)
- Prostate Cancer UK (GB)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- ASST Fatebenefratelli Sacco (IT)
- University of Turin (IT)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1158/1078-0432.ccr-23-3991
- Citations
- 11
- Primary Topic
- Vascular Tumors and Angiosarcomas
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- Cancer Research UK