Frequency and Longitudinal Course of Behavioral and Neuropsychiatric Symptoms in Participants With Genetic Frontotemporal Dementia
We identified multiple clusters of behavioral and neuropsychiatric symptoms in participants with genetic FTD that relate to distinct cerebral atrophy patterns. Their severity depends on time, affected gene, sex, and education. These clinical-genetic associations can guide diagnostic evaluations and the design of clinical trials for new disease-modifying and preventive treatments.
Authors
- Elisabeth Wlasich (ORCID: https://orcid.org/0009-0002-2733-7511)
- Francisco J. Martínez-Murcia (ORCID: https://orcid.org/0000-0001-8146-7056)
- John Cornelis Van Swieten (ORCID: https://orcid.org/0000-0001-6278-6844)
- Sandro Sorbi (ORCID: https://orcid.org/0000-0002-0380-6670)
- J. M. Górriz (ORCID: https://orcid.org/0000-0001-7069-1714)
- Caroline Graff (ORCID: https://orcid.org/0000-0002-9949-2951)
- Sandra Loosli
- Maria Carmela Tartaglia (ORCID: https://orcid.org/0000-0002-5944-8497)
- James Benedict Rowe (ORCID: https://orcid.org/0000-0001-7216-8679)
- Alexander Gerhard (ORCID: https://orcid.org/0000-0002-8071-6062)
- Christopher Robert Butler (ORCID: https://orcid.org/0000-0002-7502-9284)
- Jonathan Vöglein (ORCID: https://orcid.org/0000-0002-5965-838X)
- Matthis Synofzik (ORCID: https://orcid.org/0000-0002-2280-7273)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Alexandre de Mendonça (ORCID: https://orcid.org/0000-0002-0488-1453)
- Eve Ferry‐Bolder (ORCID: https://orcid.org/0009-0006-5083-0901)
- Raquel Sánchez‐Valle (ORCID: https://orcid.org/0000-0001-7750-896X)
- Sonja Schönecker (ORCID: https://orcid.org/0000-0003-4499-7861)
- Anna Brauer
- Harro Seelaar (ORCID: https://orcid.org/0000-0003-1989-7527)
- Pietro Tiraboschi (ORCID: https://orcid.org/0000-0002-2171-1720)
- Josef Priller (ORCID: https://orcid.org/0000-0001-7596-0979)
- Phoebe H. Foster (ORCID: https://orcid.org/0000-0001-6300-6598)
- Florence Pasquier (ORCID: https://orcid.org/0000-0001-9880-9788)
- Arabella Bouzigues (ORCID: https://orcid.org/0000-0002-0267-8590)
- Isabel Santana (ORCID: https://orcid.org/0000-0002-8114-9434)
- Lize Corrine Jiskoot (ORCID: https://orcid.org/0000-0002-1120-1858)
- Günter U. Höglinger (ORCID: https://orcid.org/0000-0001-7587-6187)
- Lucy Louise Russell (ORCID: https://orcid.org/0000-0001-5023-5893)
- Jonathan D. Rohrer (ORCID: https://orcid.org/0000-0002-6155-8417)
- Markus Otto (ORCID: https://orcid.org/0000-0003-4273-4267)
- Rik R. Vandenberghe (ORCID: https://orcid.org/0000-0001-6237-2502)
- Elizabeth C. Finger (ORCID: https://orcid.org/0000-0003-4461-7427)
- Catharina Prix
- Nicolai Franzmeier (ORCID: https://orcid.org/0000-0001-9736-2283)
- Daniela Galimberti (ORCID: https://orcid.org/0000-0002-9284-5953)
- Adrian Danek (ORCID: https://orcid.org/0000-0001-8857-5383)
- Mario Masellis (ORCID: https://orcid.org/0000-0002-6244-2096)
- Robert Laforce (ORCID: https://orcid.org/0000-0002-2031-490X)
- Olivia Wagemann (ORCID: https://orcid.org/0000-0003-3211-9105)
- Barbara Borroni (ORCID: https://orcid.org/0000-0001-9340-9814)
- J. Denecke
- Fermín Moreno (ORCID: https://orcid.org/0000-0001-5200-3164)
- Simon Ducharme (ORCID: https://orcid.org/0000-0002-7309-1113)
- Isabelle Le Ber
Institutions
- L-3 Communications (United States) (US)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Neurology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1212/wnl.0000000000209569
- Citations
- 6
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 2.21
Funders
- Biogen
- Weston Brain Institute
- Ionis Pharmaceuticals
- National Institute for Health and Care Research
- European Commission
- Deutsche Forschungsgemeinschaft
- Ministero della Salute
- Eisai
- Ministerio de Ciencia e Innovación
- Junta de Andalucía
- Bayer Vital
- Canadian Institutes of Health Research
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre
- Janssen Pharmaceuticals