The Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT-HFpEF): Rationale and Design
SPIRRIT-HFpEF will be informative on the effectiveness of generic MRAs in HFpEF and HFmrEF, and on the feasibility of conducting pragmatic and registry-based trials in heart failure and other chronic conditions.
Authors
- Jerome L. Fleg (ORCID: https://orcid.org/0000-0002-7211-5603)
- Magnus Nygren (ORCID: https://orcid.org/0000-0002-8061-7208)
- Michael Fu (ORCID: https://orcid.org/0000-0001-8860-1051)
- Tymon Pol (ORCID: https://orcid.org/0000-0001-6239-199X)
- Patric Karlström (ORCID: https://orcid.org/0000-0002-2441-0245)
- Bertram Pitt (ORCID: https://orcid.org/0000-0001-7703-0345)
- Marat Fudim (ORCID: https://orcid.org/0000-0002-8671-7007)
- Patrice Desvigne‐Nickens (ORCID: https://orcid.org/0000-0003-1073-641X)
- Lars H. Lund (ORCID: https://orcid.org/0000-0003-1411-4482)
- Eric David Peterson (ORCID: https://orcid.org/0000-0002-5415-4721)
- Kevin J. Anstrom (ORCID: https://orcid.org/0000-0001-6452-2172)
- Johan Sundström (ORCID: https://orcid.org/0000-0003-2247-8454)
- Ulf Dahlström (ORCID: https://orcid.org/0000-0001-6353-8041)
- Jonas Oldgren (ORCID: https://orcid.org/0000-0002-9969-3921)
- Camilla Hage (ORCID: https://orcid.org/0000-0002-4142-2416)
- Keith D. Aaronson (ORCID: https://orcid.org/0000-0003-1538-576X)
- Claes Held (ORCID: https://orcid.org/0000-0001-9402-7404)
- Shelly Sapp
- Song Yang (ORCID: https://orcid.org/0000-0002-3051-5844)
- Ollie Östlund (ORCID: https://orcid.org/0000-0001-8028-2308)
- Adam D. DeVore (ORCID: https://orcid.org/0000-0002-4679-2221)
- Stefan James
Institutions
- Linköping University (SE)
- University of North Carolina at Chapel Hill (US)
- Uppsala University (SE)
- Karolinska University Hospital (SE)
- Uppsala University Hospital (SE)
- Duke University (US)
- Karolinska Institutet (SE)
- UNSW Sydney (AU)
- Clinical Research Institute (US)
- National Heart, Lung, and Blood Institute (US)
- The George Institute for Global Health (AU)
- Michigan Medicine (US)
- The University of Texas Southwestern Medical Center (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1002/ejhf.3453
- Citations
- 22
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 7.24
Funders
- U.S. Department of Health and Human Services
- Hjärt-Lungfonden
- Vetenskapsrådet
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Center for Advancing Translational Sciences