Low-dose SAHA enhances CD8+ T cell-mediated antitumor immunity by boosting MHC I expression in non-small cell lung cancer
Low-dose SAHA enhances CD8<sup>+</sup> T cell-mediated antitumor immunity by boosting MHC I expression in NSCLC cells. Thus, we revealed a key mechanism of SAHA-mediated enhanced antitumor immunity, providing insights into a novel immunotherapy strategy for NSCLC.
Authors
- Yanjiao Hou
- Bing He (ORCID: https://orcid.org/0009-0000-4970-4226)
- Yujie Kong (ORCID: https://orcid.org/0000-0002-5745-3575)
- Baolong Wang (ORCID: https://orcid.org/0000-0001-7441-2428)
- Dapeng Lu (ORCID: https://orcid.org/0000-0003-2283-894X)
- Shihao Yu
- Shuang Zhang (ORCID: https://orcid.org/0000-0001-7471-6165)
- Chen Wang (ORCID: https://orcid.org/0000-0001-6849-6362)
- Zheng Xu (ORCID: https://orcid.org/0000-0002-5374-4121)
- Rui Yang (ORCID: https://orcid.org/0000-0003-4985-5344)
- Wenqian Dong
- Dechun Cui
- Yanhong Cao
- Maoxin Zhu
- Hao Wang (ORCID: https://orcid.org/0009-0008-4494-6793)
Institutions
- University of Science and Technology of China (CN)
- Anhui University of Science and Technology (CN)
- Anhui Medical University (CN)
- Anhui Provincial Hospital (CN)
- Dezhou University (CN)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1007/s13402-024-00989-9
- Citations
- 6
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 1.44
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Anhui Province
- University Natural Science Research Project of Anhui Province
- Fundamental Research Funds for the Central Universities