Rapid imaging of intravenous gadolinium-based contrast agent (GBCA) entering ventricular cerebrospinal fluid (CSF) through the choroid plexus in healthy human subjects
These results provided direct imaging evidence that GBCAs can pass the BCSFB in the CP and enter ventricular CSF immediately after intravenous administration in healthy human brains. Besides, our results in healthy subjects established a basis for clinical studies in brain diseases exploiting GBCA-enhanced MRI to detect BCSFB dysfunction.
Authors
- Linda Knutsson (ORCID: https://orcid.org/0000-0002-4263-113X)
- Adrian Paez (ORCID: https://orcid.org/0000-0003-0225-4453)
- Peter B. Barker (ORCID: https://orcid.org/0000-0002-6410-7793)
- Peter C.M. van Zijl (ORCID: https://orcid.org/0000-0002-9706-1066)
- Jay J. Pillai (ORCID: https://orcid.org/0000-0002-8306-7192)
- Chunming Gu (ORCID: https://orcid.org/0000-0003-3568-2032)
- Bryan K. Ward (ORCID: https://orcid.org/0000-0001-5201-6117)
- Jun Hua (ORCID: https://orcid.org/0000-0001-5481-7380)
- Jacob M. Pogson (ORCID: https://orcid.org/0000-0002-6523-6642)
- Yinghao Li (ORCID: https://orcid.org/0000-0002-2043-9067)
- Di Cao (ORCID: https://orcid.org/0000-0002-2196-0639)
- Yuanqi Sun
- Arnold Bakker
Institutions
- Kennedy Krieger Institute (US)
- Mayo Clinic (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1186/s12987-024-00571-3
- Citations
- 9
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 2.41
Funders
- Foundation for the National Institutes of Health
- Johns Hopkins University
- National Institutes of Health
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke
- National Institute of Biomedical Imaging and Bioengineering